Endogard plus is a broad spectrum wormer for protection against roundworms (ascarids) Hookworms, whipworms and tapeworms. With a tasty liver flavouring to make them more palatable and therefore easier to administer. exp date 04-2024

Endogard Plus Flavoured Dog Worming Tablet.
Endogard by Virbac is a broad spectrum wormer for protection against most types of intestinal worms commonly found in dogs. Endogard Plus, 1 tablet covers 10kg bodyweight

Endogard has 3 active ingredients (praziquantel, Pyyrantel embonate & Febantel) with proven efficiency, perfect for treatment of mixed infections by nematodes and cestodes.

• High safety margin
• A well tolerated combination in dogs
• Use during pregnancy (except in the first 4 weeks) or lactation
• For dogs older than 2 weeks and over 2kg in weight

Suggested dosage is every 3 months.

It is believed that virtually all dogs will carry some worms in their gut at some time. A few worms do not normally cause disease, though a large build up left untreated can cause weight loss, vomiting, diarrhoea, abdominal bloating and sometimes abdominal discomfort.
Regular worming is the best policy to prevent the possibility of worms. This is especially important for dogs which mix regularly with young children.

Manufacturer: Virbac
Qualitative and quantitative composition

Praziquantel 50 mg

Pyrantel embonate 144 mg

Febantel150 mg
Pharmaceutical form

Tablets.

Round, yellow, uncoated tablets with visible darker spots and bevelled edges with cross line on one side and plain on other side.

The tablets can be divided into equal halves or equal quarters.
Clinical particulars
Target species

Dogs, small and medium sizes
Indications for use

For the treatment of mixed infestations with the following roundworms and tapeworms in adult dogs and puppies:

Nematodes

Ascarids: Toxocara canis, Toxascaris leonina (late immature forms and mature forms)

Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults)

Cestodes

Tapeworms: Taenia spp., Dipylidium caninum
Contra-indications;

• Do not use simultaneously with piperazine compounds.

• Do not exceed the stated dosage when treating pregnant bitches.

• Do not use in animals with a known hypersensitivity to the active substance or to any of excipients.

• Not for use in dogs younger than 2 weeks of age and/or weighing less than 2 kg.

Special warnings for each target species

Fleas serve as intermediate hosts for one common type of tapeworm – Dipylidium caninum. Tapeworm infestation is certain to re-occur unless control of intermediate hosts as fleas, mice etc is undertaken.
Special precautions for use

Special precautions for use in animals

Any part-used tablets should be discarded.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In the interests of good hygiene, persons administering the tablet directly to a dog or by adding it to the dog's food should wash their hands afterwards.

In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.
Adverse reactions

In rare cases transient loose faeces, diarrhoea and/or vomiting may occur in some puppies.
Use during pregnancy, lactation or lay;

Consult a veterinary surgeon before treating pregnant animals for roundworms.

The product may be used during lactation.

Do not use in bitches during the first two-thirds of pregnancy.
Interactions

Do not use simultaneously with piperazine as the anthelmintic effects of pyrantel and piperazine (used in many worming products for dogs) may be antagonized.

Concurrent use with other cholinergic compounds can lead to toxicity.
Amounts to be administered and administration route

For oral administration.

Dosage

• The recommended dose rates are: 15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 10 kg bodyweight.

• Tablets may be halved/quartered to allow accuracy of dosing.

Administration and Duration of Treatment;

• The tablet(s) can be given directly to the dog or disguised in food. No restriction of access to food is required either before or after administration of the product.

• To ensure administration of a correct dose, body weight should be determined as accurately as possible.

• Puppies may be wormed with this product from 2 weeks of age and every 2 weeks until 12 weeks of age. Thereafter they should be treated at 3 monthly intervals. It is advisable to treat the bitch at the same time as the puppies.

• For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every 2 weeks until weaning.

• For routine control a single dose is recommended at 3 monthly intervals.

In the event of a heavy roundworm infestation, a repeat dose should be given after 14 days.
Overdose;
Benzimidazoles possess wide safety margin. Pyrantel is not absorbed systematically to any extent. Praziquantel also has a wide safety margin, of up to five times the recommended dose.

Withdrawal periods;
Not applicable

Pharmacological particulars
Pharmacodynamic properties

The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances: febantel, pyrantel embonate (pamoate) and praziquantel, a partially hydrogenated pyrazino-isoquinoline derivative used widely as an anthelmintic for both human and veterinary use. Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastro-intestinal (GI) system by peristalsis.

With the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerization. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2 – 3 days later.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vitro and in vivo studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

In this fixed combination product pyrantel and febantel act synergistically against all relevant nematodes (ascarids and hookworms) in dogs. In particular, the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala and Ancylostoma caninum. The spectrum of activity of praziquntel covers also cestode species in dogs, in particular all Taenia spp.and Dipylidium caninum,. Praziquantel acts against adult and immature forms of these parasites.
Pharmacokinetic properties

Perorally administered praziquantel is absorbed almost completely from the intestinal tract. After absorption, the drug is distributed to all organs. Praziquantel is metabolized into inactive forms in the liver and secreted in bile. It is excreted within 24 hours to more than 95% of the administered dosage. Only traces of non-metabolised praziquantel are excreted.

The pamoate salt of pyrantel has low aqueous solubility, an attribute that reduces absorption from the gut and allows the drug to reach and be effective against parasites in the large intestine. Because of the low systemic absorption of pyrantel pamoate, there is very little danger of adverse reactions/toxicity in the host. Following absorption, pyrantel pamoate is quickly and almost completely metabolized into inactive metabolites that are excreted rapidly in the urine.

Febantel is absorbed relatively rapidly and metabolized to a number of metabolites including fenbendazole and oxfendazole, which have anthelmintic activity.
Pharmaceutical particulars
Excipients;  Lactose Monohydrate, Maize Starch, Povidone K-30, Sodium Lauryl Sulfate, Microcrystalline Cellulose, Colloidal Anhydrous Silica, Magnesium Stearate, Meat Flavour
Major incompatibilities;
None known

Special precautions for storage;
This medicinal product does not require any special storage conditions.

Disposal;

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.